Born in Mexico City, Andrew Gerzso studied flute and composition at the New England Conservatory in Boston, California Institute of the Arts in Los Angeles and the Royal Conservatory in The Hague.
As a member of IRCAM's permanent staff since 1977 he has held over the years a number of positions: researcher, Technical Director, Director of Musical Research, Director of the Production Department and Manager of the IRCAM Forum, the institute's software user group. Since 2002 he is the director of the pedagogical department, coordinator of the Pôle Spectacle and is in charge of organizing the interaction between the artistic and scientific sectors of the institute. He has published articles on computer music in journals such as La Recherche, Pour la Science, Scientific American and Leonardo.
Since 1980 he has been a close collaborator of Pierre Boulez at IRCAM (for whom he did the electro-acoustic realization for Répons in 1981, Dialogue de l'Ombre Double in 1985, Explosante-fixe in 1991 and Anthèmes 2 in 1997) and at the College de France (for the annual seminars until 1995). The Deutsche Grammophon recordings of Explosante-fixe and Répons received Grammy awards in 1996 and 1999 respectively.